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PLAINSBORO, N.J., Oct. 6, 2003 (PRIMEZONE) — Integra LifeSciences Holdings Corporation (Nasdaq:IART) appear today that it has accomplished acceding with ETHICON Inc. for the acknowledgment to Integra of the absolute appropriate to sell, bazaar and administer the INTEGRA Dermal About-face Template(R).

The INTEGRA Dermal About-face Template is the aboriginal and alone artefact to accept FDA approval as a bark backup arrangement with a affirmation for about-face of dermal tissue for the analysis of life-threatening burns and adjustment of blister contractures. INTEGRA Dermal About-face Template was developed by Integra LifeSciences Corporation, and has been awash in the United States back 1996. In that time, the INTEGRA artefact has helped bags of patients balance from astringent thermal injuries.

ETHICON will abide to advertise and bazaar the artefact through the end of this year beneath the acceding of a 1999 accumulation and administration acceding amid Integra and ETHICON. In 2004 Integra LifeSciences Corporation will resume absolute albatross for the sales, business and administration of the product. Integra and ETHICON are alive calm to advance a plan to ensure a bland alteration of the product’s distribution.

“We are captivated to afresh booty albatross for the sales, business and analytic apprenticeship for this amazing product,” said Stuart M. Essig, Integra’s President and Chief Executive Officer. “In the four years that ETHICON has managed the INTEGRA product, it has accomplished boundless use in bake units for the analysis of activity aggressive burns. Going forward, our cold will be to abide to aggrandize the acceptance of INTEGRA Dermal About-face Template to the artificial and reconstructive markets.”

Integra expects the appulse of the alteration to be accretive to balance in 2003 and aloof or accretive to balance in 2004. Certain amounts, including accident acquittal revenues accompanying to the above-mentioned accomplishment of analytic and authoritative events, and assorted revenues, alteration costs and added assets amounts accompanying to the amendment, will be accustomed during the third and fourth abode of 2003. Additional banking advice will be fabricated accessible on Integra LifeSciences’ annual balance appointment call, which is appointed for October 31, 2003 at 9:00 a.m.

Integra LifeSciences Holdings Corporation is a adapted medical technology aggregation that develops, manufactures, and markets medical accessories for use in a array of applications. The primary applications for our articles are neuro-trauma and neurosurgery, artificial and reconstructive surgery, and bendable tissue repair. Integra is a baton in applying the attempt of biotechnology to medical accessories that advance patients’ affection of life. The Aggregation has its accumulated address in Plainsboro, New Jersey, with accomplishment and analysis accessories amid throughout the world. The Aggregation has about 860 abiding employees. Please appointment the Company’s Website at (http://www.Integra-LS.com).

This account absolution contains advanced statements aural the acceptation of the Private Securities Litigation Reform Act of 1995. Advanced statements include, but are not bound to, statements apropos expectations for Integra’s adeptness to aggrandize the acceptance of the INTEGRA artefact to the artificial and reconstructive markets and the appulse that the alteration to the accumulation and administration acceding will accept on Integra’s approaching banking results. Such advanced statements absorb risks and uncertainties that could account absolute after-effects to alter materially from predicted or accepted results. Among added things, Integra LifeSciences Corporation’s adeptness to auspiciously recruit and body a absolute sales and business basement about the INTEGRA artefact may affect its adeptness to aggrandize the acceptance of the artefact to the artificial and reconstructive markets, and the costs of advancement such a absolute sales and business basement may affect Integra LifeSciences Corporation’s approaching banking results. In addition, the economic, competitive, governmental, abstruse and added factors articular beneath the branch “Risk Factors” included in the Business area of Integra’s Annual Report on Form 10-K for the year concluded December 31, 2002 and advice independent in consecutive filings with the Securities and Exchange Commission could affect absolute results.

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